If you want to download the file from Rapidshare or Megaupload frequently, a suitable download manager is needed. This type of websites for file hosting is called one-click hosting. So, I have tried several downloaders, not only support Rapidshare and Megaupload, but also other sites like hotfile.com, badongo.com, sendspace.com, etc.
Universal Share Downloader – Russian freeware. First file hosting downloader I used. Good.
RapGet – I always failed to download the file using it.
RDesc – Spanish freeware. Not bad. Just as good as Universal Share Downloader.
JDownloader – Just found it recently. Very good. Requires JRE.